In this case, the resistant cells exhibit an enhanced proliferative, clonogenic capacity, with a significant up-regulation of P-glycoprotein (ABCB1), c-Myc, survivin, and beta-catenin and a putative cancer-stem-like signature, with an increased expression of CD44, whereas they display a loss of E-cadherin [100]. Here, ABCB1 is linked to cancer.