As indicated by immunohistochemistry (IHC) staining of vascular endothelial growth factor receptor 2 (VEGFR2) (Figure 7F), Oligo-Fucoidan (F) alone or combined treatment (C + F) also repressed the angiogenesis effect in the p53+/+ and p53−/− tumors, while cisplatin only well inhibited the p53+/+ tumor angiogenesis. The gene discussed is TP53; the disease is neoplasm.