In study of the primary C6P2-L1 cell lines derived from the colorectal cancer patients (Figure 5), we also identified that Oligo-Fucoidan supplementation advanced cisplatin effect on inducing the PARP (Asp214) cleavage and caspase 3 activation (Figure 5A), thus evolving the apoptotic events more than the individual treatments (Figure 5B). Here, CASP3 is linked to colorectal cancer.