When DPI suppressed intracellular ROS (Figure 2A) and mitochondrial superoxide levels (Figure 2B), the phosphorylation of p47phox (Ser345) was significantly decreased by DPI independent of the p53 status (Figure 2C) and DPI dramatically induced the active phosphorylation of p53 (Ser15) and the accumulation of p53 in the p53+/+ cancer cells. Here, TP53 is linked to cancer.