Oligo-Fucoidan supplementation not only advanced cisplatin’s cytotoxic effects on colon cancer cells (Figure 4D,E) and breast cancer cells (Figure 5), Oligo-Fucoidan also promoted TGF-β receptor degradation and Toll-like receptor 4-mediated pathway to induce ER stress [51,52], which triggered lung cancer cell death and executed a tumor-suppressing mechanism [51]. The gene discussed is TLR4; the disease is breast cancer.