ALK and non-small cell lung carcinoma: Since then, various gene rearrangements (fusions), mutations, amplification, and alternative splicing events of ALK have been identified in several human cancers, including ALCL, inflammatory myofibroblastic tumor (IMT), non-small cell lung cancer (NSCLC), and cancers of the kidney, breast, colon, esophagus, the head and neck, etc. [7,8].