BRAF p.G593D has been identified in solid cell nest hyperplasia in association with BRAF p.V600E mutated PTC [14], while the BRAF p.R603Q and p.S607F mutations were reported in nevi, in association with BRAF p.V600E mutated melanomas [15], similar to what we observed in our cases. The gene discussed is BRAF; the disease is melanoma.