Flavonoids acting as pro-oxidants could suppress proliferation of cancer cells by inhibition of epidermal growth factor receptor/mitogen activated protein kinase (EGFR/MAPK), phosphatidylinositide 3-kinases (PI3K), protein kinase B (Akt) as well as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) [18,20,38]. The gene discussed is NFKB1; the disease is cancer.