NFKB1 and malignant colon neoplasm: Moreover, genistein suppressed Bcl-2, Bcl-xL, c-inhibitor of apoptosis protein 1 (c-IAP1), survivin, and NF-κB in C200 and A2780 cells [94], increased caspase-3 activity in HT-29 colon cancer cells [95] and activated intrinsic apoptotic signaling pathway in HCT-116 and LoVo cells [96].