Inflammation represents one of the most important hallmarks of psoriasis and pro-inflammatory cytokines deriving from T cells activation, such as Tumor Necrosis Factor alpha (TNF-α) and several Interleukins (IL), participate to the appearance of some psoriatic features such as epidermal hyperplasia, acanthosis, and hyperparakeratosis [2]. The gene discussed is TNF; the disease is psoriasis.