TNF and Arthritis: Animal models for rheumatoid arthritis include induced arthritis models, such as genetically manipulated, the spontaneous arthritis models, such as the TNF‐α‐transgenic mouse, K/BxN mouse and the collagen‐induced arthritis, such as collagen‐antibody‐induced arthritis, zymosan‐induced arthritis and the methylated BSA model (Choudhary, Bhatt, & Prabhavalkar, 2018).