Sensory neuropathy has been shown to influence a variety of neuronal and non‐neuronal genes in the heart including vanilloid receptor‐1 TRP protein, GABA receptor rho‐3 subunit, cytochrome P450 subfamily 2A, polypeptide 1 (CYP2A1), 5‐HT3B receptor, NK2 receptor, matrix metalloproteinase‐13, farnesyl‐transferase, Apo B apolipoprotein, leptin and endothelial NOS (Zvara et al., 2006). The gene discussed is NOS3; the disease is sensory peripheral neuropathy.