Bencsik et al. found that sensory neuropathy (chemo‐denervation) induced by 7 days of capsaicin treatment decreased the cardiac NO availability via decreased activity of Ca2+‐dependent NOS isoforms (endothelial NOS and nNOS) and increased SOD activity thereby lead to decreased basal ONOO− formation and a reduction of S‐nitrosylation of sarco‐endoplasmic reticulum Ca‐ATPase type 2a (SERCA2a), which caused impaired myocardial relaxation in the rat heart. This evidence concerns the gene NOS3 and Sensory neuropathy.