PDLIM7 and Epstein-Barr virus infection: The major previously reported phenotypic difference between T1 and T2 EBV infection in vitro is that T1 EBV transforms B cells more efficiently than T2 EBV; this difference was first reported to be due to a single amino acid difference (S442D) between the EBNA2 proteins that allows the T1 EBNA2 to bind to EICE sites and more efficiently activate several cellular genes and the LMP1 promoter [28–32].