Nevertheless, the presence of the Zp-V3 promoter variant by itself appears to not be sufficient to ensure high level lytic infection in all contexts, since we found that in EBV-infected B cells, the two T2 EBV strains (AG876 and BL5) were still more lytic compared to two T1 EBV strains (Akata and M81) that also contain the Zp-V3 variant (Figs 3B and 6C). Here, HEPHL1 is linked to infection.