In the case of LMP1, although we consistently observed decreased LMP1 expression in T2 EBV-infected lymphomas in CBH mice in vivo, we found that over time T2 EBV LCLs in vitro expressed similar levels of LMP1 as the T1 EBV lines (Fig 6), yet still retained the enhanced lytic phenotype. This evidence concerns the gene PDLIM7 and lymphoma.