Although we previously showed that NFATc1 plays a role in mediating ionomycin-induced lytic EBV reactivation in Mutu Burkitt lymphoma cells infected with a Zp-V3 containing mutant B95.8 virus [20], we have not previously explored whether the related NFATc2 protein is expressed in LCLs or Burkitt lines, and whether this factor is also required for Zp-V3 activation by calcium signaling pathways. The gene discussed is NFATC1; the disease is Burkitt lymphoma.