For example, there was a positive match to a CREB3L1/OASIS motif, a transcription factor involved in the bone formation.63 Mutations in CREB3L1 have been linked to osteogenesis imperfecta.64, 65, 66 There was a match to ELF3, a transcription factor important during chondrogenesis67 and in cartilage degradation in OA.68, 69 Other matches include the HES and HEY family of transcription factors that are involved in chondrocyte hypertrophy during development 70, 71 (Table S6). This evidence concerns the gene CREB3L1 and osteogenesis imperfecta.