Similarly, it has been reported that Ki-67 expression has improved prognostic significance when stratified according to HPV status in HPV-induced head and neck squamous cell carcinomas.17 The best survival outcomes were identified in HPV-positive, Ki-67–negative tumors and the worst in HPV-negative, Ki-67–positive HPV-induced head and neck squamous cell carcinomas. This evidence concerns the gene MKI67 and head and neck squamous cell carcinoma.