Increased levels of MCM indicate proliferation of malignant cells as expressed in several types of cancers and is possibly more accurate than Ki-67 as a marker of proliferation.26,27 Persistent expression of MCM2, MCM5, and Ki-67 may be diagnostic markers in Barrett dysplasia.28 Furthermore, MCMs can predict tumor progression and thus are prognostic markers. The gene discussed is MCM2; the disease is cancer.