HAVCR2 and melanoma: Active cores had, together with more active Tcy (p-val <0.001), higher percentages of Tcy in transition (p-val = 0.030), transition cores more Th (p-val = 0.057), while exhausted cases had more TIM3+Tregs (p-val = 0.018) and more proliferating melanoma cells (p-val = 0.045) (Figure 4C).