On the other hand, cell-cell interactions specific for exhausted cases included: CD69+TIM3+Th and anergic Tcy, anergic Tcy and active Th, anergic Tcy and BC expressing INFgamma, CD69+TIM3+Th and TIM3+cDC2, TIM3+macrophages and transition Tcy, NK and PD-L1+pDC, and the different subtypes of Tfh and cDC1. The gene discussed is MPPE1; the disease is breast cancer.