Despite LRRK2 having been implicated in a variety of cellular processes, including cytoskeletal dynamics (Civiero et al., 2018; Kett et al., 2012; Pellegrini et al., 2017), vesicular trafficking (Herbst and Gutierrez, 2019; Sanna et al., 2012; Shi et al., 2017), calcium signaling (Bedford et al., 2016; Calì et al., 2014), and mitochondrial function (Ryan et al., 2015; Singh et al., 2019; Yue et al., 2015), its precise mechanistic contributions to triggering and/or exacerbating PD and other disease pathologies are not known. The gene discussed is LRRK2; the disease is Parkinson disease.