Interestingly, expression of several non-ISG, non-immune genes was reduced in uninfected Lrrk2 KO BMDMs, including ApoE, which has been repeatedly linked to inflammatory and neurodegenerative diseases, and Ldhb, a critical metabolic gene involved in post-glycolytic energy production (Figure 1G). The gene discussed is APOE; the disease is neurodegenerative disease.