Loss of LRRK2 reduces IL-1β secretion in response to Salmonella enterica infection in macrophages (Liu et al., 2017) and enhances expression of pro-inflammatory cytokines in response to Mycobacterium tuberculosis (Mtb) infection at early time points of mouse infection (Härtlova et al., 2018). Here, LRRK2 is linked to tuberculosis.