Several studies indicate that the absence of IL‐1 signalling is protective in central nervous system diseases characterised by neuroinflammation (Trittibach et al, 2008; van Strien et al, 2010; Murray et al, 2013; Wohleb et al, 2014; Clausen et al, 2016; Zhang et al, 2017). The gene discussed is IL1A; the disease is central nervous system disorder.