Questions remain as to the relationship between TNF‐α‐induced RIPK activation and necroptosis‐mediated cell death described in Gaucher disease (Vitner et al, 2014) and Niemann‐Pick C (Cougnoux et al, 2016), versus NLRP3‐mediated IL‐1 secretion and downstream effects described here in MPSIIIA, as well as inflammasome activation which has also been reported in Gaucher macrophages (Aflaki et al, 2016). Here, NLRP3 is linked to mucopolysaccharidosis type 3A.