CTSB and mucopolysaccharidosis type 3A: Whilst primary HS storage clearly initiates a priming of a danger‐associated molecular pathogen (DAMP) type innate immune response in MPSIIIA, we cannot preclude the possibility that distention of lysosomes and resulting lysosomal membrane permeabilisation, releasing cathepsin B, may also be a secondary initiator of the NLRP3 inflammasome.