MiR‐34a aggravates coxsackievirus B3‐induced cardiomyocyte apoptosis through the SIRT1‐p53 pathway.37 In our study, we reported miR‐34a was up‐regulated in PE‐treated cardiomyocytes and in hypertrophic hearts of mice induced by TAC; TUG1 sponged and sequestered miR‐34a to attenuate the inhibitory effect of miR‐34a on DKK1, which prevented cardiac hypertrophy. The gene discussed is SIRT1; the disease is cardiac hypertrophy.