Mandibuloacral dysplasia is an extremely rare autosomal recessive progeroid syndrome due to mutations in genes encoding nuclear lamina proteins, lamins A/C (LMNA) or prelamin A processing enzyme, and zinc metalloproteinase (ZMPSTE24) which has been reported in approximately 40 case reports [61, 62]. Here, LMNA is linked to mandibuloacral dysplasia.