While anti-myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) were originally linked especially to acute disseminated encephalomyelitis (ADEM)-like presentation in pediatric patients [6, 7], more recent studies proposed a wider clinical spectrum including uni- and bilateral optic neuritis (ON), short and longitudinal extensive transverse myelitis (LETM), brainstem and cerebellar lesions or seizures [8–15]. The gene discussed is MOG; the disease is optic neuritis.