Pressure-volume loop analysis and RNA expression analysis of Rcan-1, ANP, and BNP as heart failure and hypertrophy markers; Col1a2 as a fibrosis marker; and SERCA2a and PLB as calcium regulatory markers were performed after 4 weeks of administration of 0.2% DS37001789 in TAC mice. The gene discussed is NPPB; the disease is heart failure.