UTS2R and persistent truncus arteriosus: In GPR14 KO TAC mice, EF (GPR14 KO TAC mice vs. WT TAC mice: 42.8 ± 1.5% vs. 33.6 ± 1.5%), LVDd (GPR14 KO TAC mice vs. WT TAC mice: 4.8 ± 0.1 mm vs. 5.3 ± 0.1 mm), and LVDs (GPR14 KO TAC mice vs. WT TAC mice: 3.9 ± 0.2 mm vs. 4.6 ± 0.1 mm) were significantly ameliorated from 1 week after TAC operation compared with those in WT TAC mice (P < 0.05, Figure 9), whereas LV hypertrophy was similar to that in WT mice (Figure 10).