ANO1 and cystic fibrosis: In the present study, UTP activated little CaCC activity in CF cells, probably due to low levels of expression of the CaCC TMEM16A.34,35 By contrast, in the pro-inflammatory conditions of the CF lung, CaCC activity is enhanced strongly by increased TMEM16A expression.35,50 Encouragingly, the present results show that the activity of some anionophores, particularly the tren 19, is additive to CaCC activation.