CFTR and cystic fibrosis: Moreover, patients who are helped by treatment with CFTR correctors/potentiators may benefit further from complementary approaches, such as anion-transporting small molecules, which restore bacterial killing to CF cells.54 Encouragingly, the present results and ref. 41 demonstrate that the action of anionophores is additive to the clinically-licensed CFTR modulators lumacaftor and ivacaftor, raising the possibility that combination therapy with anionophores and CFTR modulators might be used to treat CF patients.