CFTR and cystic fibrosis: To learn whether anionophores are additive to small molecules that rescue disease-causing CFTR variants, we used FRT cells co-expressing F508del-CFTR, the predominant CF mutation and YFP-H148Q/I152L (F508del-CFTR-YFP-FRT cells).28 To rescue the plasma membrane expression of F508del-CFTR, we used low temperature or the clinically-licensed CFTR corrector lumacaftor,38,39 while to increase its activity, we used the clinically-licensed CFTR potentiator ivacaftor.40