To validate this notion, we analyzed publically available MYC-ChIPseq data of HepG2 liver cancer cells from ENCODE (ENCSR000DLR) and found that of the 3509 genes with MYC-binding sites, 512 genes were deregulated by HES5wt (Supplementary Fig. S7 and Supplementary Table S6). The gene discussed is MYC; the disease is liver cancer.