For example, in The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) HCC data set (N = 364), only six genes were found to be significantly mutated in >5% of patients, namely TP53, CTNNB1, ALB, AXIN1, ARID1A, and APOB [3]. Here, CTNNB1 is linked to hepatocellular carcinoma.