It is well established that tumor antigen-specific T cells gradually acquire an exhausted phenotype within the TME, which is characterized by upregulation of coinhibitory molecules, including PD-1 and LAG3, and a concomitant decline in cellular proliferative capacity and functionality.26 Although PD-1 expression remained similar in both T cell populations (Fig. 3g), the expression of the inhibitory receptor LAG3 (Fig. 3h) was significantly lower in T cells with enforced PGC-1α expression compared to their SCR counterpart. This evidence concerns the gene LAG3 and neoplasm.