Recently, great interest has emerged to potentiate the efficacy of cancer immunotherapy by modulating T cell metabolism.12–22 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a key regulator of mitochondrial biogenesis (MB) and modulates OXPHOS and FAO, which are the cardinal metabolic features of T cell memory induction.23 Here, we demonstrate that CD8 T cells overexpressing PGC-1α show increased in vivo persistence and an enhanced recall response to Listeria-Ova infection or OVA peptide vaccination. The gene discussed is PPARGC1A; the disease is cancer.