This finding is in line with a previous study showing that PGC-1α is gradually decreased in TILs.20 Additionally, to further investigate the impact of chronic TCR stimulation on PGC-1α and β, we analyzed CD8 T cells 7 and 21 days post chronic Lymphocytic Choriomeningitis Virus (LCMV, clone 13) infection (Supplementary Fig. 1k). This evidence concerns the gene PPARGC1A and infection.