These molecules can enhance the cyclin-dependent kinase inhibitor 1 A (CDKN1A,p21) expression, in NSCLC cells miR-34a is able to directly suppress the Myc proto-oncogene protein (Myc)5 and the Histone deacetylase 1 (HDAC1)6 as both negatively regulate p21. This evidence concerns the gene CDKN1A and non-small cell lung carcinoma.