Angiotensin II (AngII) is a major player in the RAS16,17 and enhances ROS production by activating NOX via AngII type 1 receptor (AT1R)18–21, thus contributing to the development of various brain disorders, including stroke, traumatic brain injury and neurodegenerative diseases, as well as hypertension18,19,21–23. This evidence concerns the gene AGT and stroke disorder.