CLCN1 and myotonic dystrophy type 1: A previous study showed that 2-fold upregulation of MBNL1 protein by transduction of a recombinant adeno-associated viral vector reversed missplicing of Clcn1, Ldb3, Serca1, and Tnnt3, resulting in a significant reduction in myotonia in a DM1 mouse model17.