A previous study showed that 2-fold upregulation of MBNL1 protein by transduction of a recombinant adeno-associated viral vector reversed missplicing of Clcn1, Ldb3, Serca1, and Tnnt3, resulting in a significant reduction in myotonia in a DM1 mouse model17. The gene discussed is MBNL1; the disease is Myotonia.