IL6 and obesity due to melanocortin 4 receptor deficiency: The diet-induced animal model of NAFLD (DIAMOND) is one such model; it is an isogenic cross of a C57Bl6/J and s129svlm6 mouse which reproducibly develops obesity, adipose tissue inflammation, hypoadiponectinemia, increased IL-6 and TNF-α, insulin resistance, dyslipidemia and NAFL which progresses to NASH with histology that resembles human NASH and progresses to bridging fibrosis and early nodule formation29.