Accordingly, it is worth of noticing that ATF-SAP WT was not able to kill cells expressing low or undetectable uPAR levels (grade 1 and 3 bladder cancer and HER2+ breast cancer cell lines), meaning that a higher concentration of chimera is needed to reach an IC50, which results in a loss of receptor specificity. The gene discussed is PLAU; the disease is urinary bladder cancer.