To further corroborate their lack of sensitivity to the chimera and to validate bladder cancer as a candidate target for the proposed therapy, we extracted primary bladder-derived fibroblasts from a human bladder biopsy and, after immune-fluorescence characterization for typical fibroblasts markers, analyzed them for uPAR expression (Fig. 4A,B). The gene discussed is PLAUR; the disease is urinary bladder carcinoma.