A study by Zibell et al. 38 also found no change in brain endothelial COX-2 expression of lithium-pilocarpine status epilepticus rat model and in isolated rat brain capillaries exposed to 50 μM and 100 μM glutamate and reported that seizure induction has no effect on COX-2 expression but causes enhanced substrate (arachidonic acid) flux to COX-2. Here, PTGS2 is linked to status epilepticus.