To further demonstrate that linked-read WGS allows detection of other aberrations than large-scale aneuploidies and translocations, we screened the 12 ALL genomes for focal deletions in a set of relevant genes for ALL, including BTG1, CDKN2A/B, EBF1, ETV6, IKZF1, PAX5, RB1 and ERG25 (Fig. S12). Here, PAX5 is linked to acute lymphoblastic leukemia.