TP53 and neoplasm: As shown in Supplementary Fig. 2a and Supplementary Table 2, both foci from the right-sided tumor (B2 and B3) showed an arm-level deletion of chromosome 10q encompassing PTEN and a focal deletion in chromosome 17p encompassing TP53. However, the left-sided tumor (B1) showed no genomic hits to PTEN or TP53 (Supplementary Fig. 2a), suggesting a noncoding or epigenetic driver of reduced PTEN expression.