Using the TMPRSS2:ERG fusion as a putative early driver of tumorigenesis, based on its expression in all right-sided tumor foci (B2, B3, R2, and R3), we modeled that the IDC-P and invasive foci identified in the RP descended from IDC-P and invasive foci sampled on biopsy. Here, TMPRSS2 is linked to neoplasm.