As the right-sided tumor foci (R2 and R3) displayed reduced but positive ERG staining consistent with suppression of AR activity by ADT plus enzalutamide, we confirmed using immunofluorescence that the right-sided tumor was ERG-positive and distinct from the left-sided tumor (R1), which was ERG-negative (Supplementary Fig. 3c). The gene discussed is AR; the disease is neoplasm.