For example, miR-29 mediates TGF-β1-induced ECM synthesis through activating Wnt/β-catenin pathway in human pulmonary fibroblasts43; in breast cancer tissues, miR-29 inhibits ECM network genes44; in pancreatic cancer, loss of miR-29 is correlated with a significant increase in ECM deposition45. This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.