MFAP2 and osteosarcoma: The intracellular form of MFAP2 can induce the transcription of integrin α4 in human osteosarcoma cell line SAOS-213; in vascular development, MFAP2 defect will result in the reduction of integrin–matrix interaction36; our findings highlight the capability of MFAP2 to modify the phenotype of GC cells, partly by upregulating integrin α5β1.