To further verify the crucial role of matrix remodeling in GC progression, we conducted survival analysis and obtained 14 genes associated with prognosis of GC patients, including SPARC, MFAP2, SERPINE1, LOX, PDGFRB, OLFML2B, VCAN, COLA18A1, SPON2, COL4A2, CHD11, NRP1, NREP, and COL4A5. This evidence concerns the gene VCAN and gastric cancer.