If Larp6 proteins regulate type 1 collagen production in zebrafish, larp6 mutants might have severe phenotypes similar to type 1 collagen subunit mutations that produce the various bone dysplasias, such as osteogenesis imperfecta (Asharani et al., 2012; Fisher et al., 2003; Van Eeden et al., 1996). This evidence concerns the gene LARP6 and osteogenesis imperfecta.