The p.E318K variant of MITF in melanoma and renal carcinoma cells severely impaired SUMOylation of MITF, resulting in an increased transcription of HIF1A and other genes compared to wild-type MITF. Even under normoxic conditions, the p.E318K variant allows cancer cells to activate a pseudohypoxic response or aerobic glycolysis and this “Warburg effect” predispose to cancer progression and metastasis [10]. The gene discussed is HIF1A; the disease is cancer.