When we analyzed the global patterns of DN and melanomas, grouped together as a single variable, the unspecific, globular-homogenous and reticular-homogenous patterns were more frequent in MITF+ compared to MITF− patients; conversely, the multicomponent pattern was more common in MITF− than in MITF+ patients, as shown in Table 2 (p < 0.001). This evidence concerns the gene MITF and melanoma.