TNF and graft versus host disease: Accordingly, immunologically relevant signaling pathways (TNF, toll-like receptor (TLR), IL-17, etc.)and biological process (graft-versus-host disease (GvHD), cell adhesion molecules (CAM), cell cycle and differentiation, etc.)were enriched as well by utilizing Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis (Fig. 3j).