STAT3 and neoplasm: Notably, the expression of c-Myc, which regulates aerobic glycolysis and promotes tumor progression in various cancer [33], were correlated with phosphorylation levels of STAT3 (Fig. 3Aa and Ab), and overexpression of eEF2K markedly decreased STAT3 phosphorylation, but not total STAT3 expression, with corresponding reduction of c-Myc expression (Fig. 3B).