Recently years, PKM2 has been extensively studied in non-glycolytic activity and exhibits various biological functions in tumor progression [21–23], for example, nuclear dimer PKM2 as a protein tyrosine kinase directly phosphorylates the signal transducer and activator of transcription 3 (STAT3) at T705, thereby contributing to drive cancer cell proliferation [24]. Here, PKM is linked to neoplasm.