CHCHD2 and neoplasm: The results showed that the positive stain of CHCHD2 and HIF-1a were 94.7% (198/209) and 95.7% (200/209) in tumor tissues, there were significantly higher than that in adjacent non-cancerous tissues 11.0% (23/209) and 68.9% (144/209), (P = 0.000, P = 0.000) respectively (Table 1).