Subsequently, we found that the expression of CHCHD2 in NSCLC was notably associated with some clinical parameters of NSCLC, such as smoking (P = 0.045), tumor size (P = 0.000), differentiation degree (P = 0.034), TNM stage (P = 0.000), lymph metastasis (P = 0.000). This evidence concerns the gene CHCHD2 and non-small cell lung carcinoma.