With a similar manner, we found the HIF-1α expression was significantly associated with smoking (P = 0.035), tumor category (P = 0.027), differentiation degree (P = 0.003), TNM Stage (P = 0.002), lymph metastasis (P = 0.003), however there was no significant of HIF-1α expression correlation with gender (P = 0.170), age (P = 0. The gene discussed is HIF1A; the disease is neoplasm.