Thus, the present study also focused on the correlation of CHCHD2 and HIF-1α expression in NSCLC, suggesting that CHCHD2 might interacted with HIF-1α to response hypoxia in the occurrence of NSCLC, in order to provide a basis for further study on the developmental mechanism of CHCHD2 in regards to NSCLC. Here, HIF1A is linked to non-small cell lung carcinoma.