The clinical phenotypes that are a result of different CaM mutations include long-QT syndrome (LQT), catecholaminergic polymorphic ventricular tachycardia (CPVT), and idiopathic ventricular fibrillation (IVF) have been reviewed [19,58,59]. Here, CALM1 is linked to catecholaminergic polymorphic ventricular tachycardia.