ID4 and breast cancer: High expression of ID4 in BC cells indeed enhances macrophage motility and leads to the activation of a pro-angiogenic program in TAMs, which involves both the transcriptional increase of angiogenic factors, such as granulin (GRN), and the downregulation of antiangiogenic miR-15/107 group members (e.g., miR-107, miR-15b, and miR-195) [12].