As CTGF and CYR61 are matricellular proteins important for ECM-cell interaction [32], we aim to investigate in our future studies if the ID4-driven axis in macrophages contributes to the remodeling of the ECM in breast tumors and to decipher the specific roles of the ID4 protein in the ECM-Hippo signaling cascade in TAMs. The gene discussed is CCN2; the disease is breast neoplasm.