TGFB1 and neoplasm: The pDC dysfunction can be induced by soluble factors derived from tumor cells, necrotic cells or other immune cells, such as PGE2 [160], TGF-β [161], IL-10 [162], IL-3 [163,164], Vasoactive Intestinal Peptide [165], Wnt5a [166,167] and HMGB1 [168].