The results of phase III randomized trials (keynote 054, checkmate 238 and combi-AD) demonstrated an improvement in recurrence-free survival in patients with resected melanoma, who received respectively anti-PD-1 (pembrolizumab or nivolumab) or target agents (dabrafenib plus trametinib, in BRAF mutated tumors) [238,239,240]. Here, BRAF is linked to melanoma.