Another immunosuppressive effect of BRAFV600E mutant proteins is related to the down-regulation of MHC-I molecules, via a rapid and constitutive internalization of MHC-I from the melanoma cell surface and subsequent sequestration within the endocytic compartments, thus diminishing CD8+ T-cell recognition of tumor cells and facilitating tumor evasion [249]. The gene discussed is CD8A; the disease is melanoma.