Given that elevated extracellular ATP levels can be observed at the sites of vascular injury and inflammation and that purinergic receptors are druggable targets, our data may suggest that targeting P2YR purinergic receptors by selective high-affinity agonists, antagonists, and a limited number of critical TFs, could sufficiently reduce VV angiogenesis and, in turn, reduce pathologic vascular remodeling and perivascular inflammation in PH and other cardiovascular diseases. This evidence concerns the gene P2RY1 and cardiovascular disorder.