Introduction of miR-7 decreases the expression levels of EGFR, IGF-1R, CRAF in vitro as well as in Vemurafenib-resistant cells in melanoma xenograft mice models, which indicates that EGFR, IGF-1R, and CRAF are the target genes of miR-7 that are associated with the acquired resistance to BRAFi. Here, RAF1 is linked to melanoma.