Trials conducted with Imatinib mesylate, an inhibitor of KIT and other RTKs, in patients with c-KIT–mutant melanoma, have reported median times to disease progression of approximately 3 months that are significantly lower than the time to progression when Imatinib is used to treat gastrointestinal stromal tumors (GIST) (median time to progression of 18 months). Here, KIT is linked to gastrointestinal stromal tumor.