HIF1A and histiocytic sarcoma: Based on the aforementioned hypothesis, the aim of the present in vitro study was to demonstrate that histiocytic sarcoma cells (DH82 cells) persistently infected with CDV-Ond show: (1) an increased oxidative stress status, (2) an increased HIF-1α protein expression, (3) an unusual intracellular distribution of HIF-1α, and (4) a reduced expression of HIF-1α downstream targets, with a special focus on VEGF-B.