Genes whose expression is changed 5.6-times or more (log2 FC > 2.5) in at least six MPS types include LY6K, COL8A2, CAPG, CLU, ADAMTSL1, POSTN, and MFAP5, coding for lymphocyte antigen 6 family member K, alpha 2 chain of type VIII collagen, capping actin protein–gelsolin like, clusterin, ADAMTS-like 1 protein, periostin, and MFAP5 glycoprotein, respectively. The gene discussed is LY6K; the disease is mucopolysaccharidosis.