However, Ma et al., reported that although the levels of p-mTOR, p-4E-BP1 and p-S6K1 were significantly higher in breast tumor tissues compared to normal tissues, the status of phosphorylated mTOR, 4E-BP1 and S6K1 could not serve as prognostic factors for breast cancer [107]. This evidence concerns the gene EIF4EBP1 and breast carcinoma.