One good example is the fabrication of a label-free aptasensor device on 10.5 × 35.0-mm2 pieces of Whatman chromatography paper grade No. 1 for the simultaneous multiplexed detection of two cancer biomarkers, namely carcinoembryonic antigen (CEA) and neuronspecific enolase (NSE), in clinical samples. Here, CEACAM5 is linked to cancer.