The most significant DCM genes, which should be always tested are: TTN, LMNA, MYH7, TNNT2, BAG3, RBM20, TNNC1, TNNI3, TPM1, SCN5A, PLN, and FLNC [26,27]; while there are a number of other minor genes that have been associated with DCM, but should be screened only in selected cases [28]. This evidence concerns the gene PLN and familial dilated cardiomyopathy.