NOS2 and colitis: In rodent models of colitis, treatment with H2S-donors significantly reduced tissue expression of IL-1β, interferon-γ, TNF-α, IL-12 p40, IL-2, regulated upon activation, normal T cell expressed and presumably secreted (RANTES), and inducible nitric oxide synthase (iNOS), without affecting the IL-10 expression [71,74,75].