FZD2 and cancer: In our study, the differentially expressed genes in DCIS compared to invasive cancer are FZD2 and SFRP2, which are the core WNT pathway components, STK31, and LALBA. FZD2 is elevated in many cancers, including breast cancer, and its expression correlated with markers of EMT and cell migration through a non-canonical pathway that predicts metastasis and overall survival in patients [22].