The regulation of MMP2 activity involves several mechanisms, such as transcription, regulation of mRNA half-life, secretion, intra- or extracellular localization, enzyme activation, and inhibition by specific and nonspecific cellular protease inhibitors [34]; thus, determining the actors responsible for such a differential regulation in BM and UCMD requires further extensive studies. The gene discussed is MMP2; the disease is Ullrich congenital muscular dystrophy.