MTOR and acute myeloid leukemia: Of interest, a peculiar metabolism seems to be associated with the resistance to PI3K/mTOR axis inhibitors: a metabolomic study carried out on 30 primary samples exposed to 4 molecular inhibitors (rapamycin, GDC-0941, human insulin, indomethacin), targeting this pathway with different selectivity, identified the proline/glutamine and the arachidonic acid metabolism as markers of AML cell resistance to these agents [71].