BIRC2 and neoplasm: In a later study, Faye and colleagues identified the dependence of RhabdoMyoSarcoma (RMS) tumors on cIAP1 and observed that LCL161 treatment of mice with established Kym-1 RMS xenograft tumors led to tumor cell death and prolonged survival (mean survival days were 46 vs. 77.69 ± SEM) [90].