CTLA4 and glioblastoma: Similarly, Beug and colleagues in an extensive and very detailed study, showed that combining the ICIs, anti-PD1 or anti-Cytotoxic T-Lymphocyte-Associated protein 4 (anti-CTLA-4), with the SM LCL161 greatly increased survival in intra-cranial mouse glioblastoma models and produced durable cures [150].