Although two of the most sensitive tumors (anaplastic large cell lymphoma Karpas-299 cell line and medulloblastoma BT-39 xenograft) showed elevated TNF expression, multiple B-precursor Acute Lymphoblastic Leukemia (ALL) xenografts, which also presented with moderate levels of TNF, were resistant to LCL161 treatment [88]. Here, TNF is linked to acute lymphoblastic leukemia.