The sets include functions such as PI3K and MAPK kinase signaling pathways, involved in HF-related cardiac hypertrophy, or fibrinolysis and coagulation processes (e.g. FGB, SERPINE1 or SERPING1) and growth factors (e.g. FGF1 or PDGF) related to MD induction. The gene discussed is SERPINE1; the disease is cardiac hypertrophy.